SMEs increasingly seek alternatives to cloud LLM APIs, which raise data privacy concerns. Dedicated cloud GPU instances offer improved privacy but with limited guarantees and ongoing costs, while professional on-premise hardware (A100, H100) remains prohibitively expensive. We present a systematic evaluation of NVIDIA's Blackwell consumer GPUs (RTX 5060 Ti, 5070 Ti, 5090) for production LLM inference, benchmarking four open-weight models (Qwen3-8B, Gemma3-12B, Gemma3-27B, GPT-OSS-20B) across 79 configurations spanning quantization formats (BF16, W4A16, NVFP4, MXFP4), context lengths (8k-64k), and three workloads: RAG, multi-LoRA agentic serving, and high-concurrency APIs. The RTX 5090 delivers 3.5-4.6x higher throughput than the 5060 Ti with 21x lower latency for RAG, but budget GPUs achieve the highest throughput-per-dollar for API workloads with sub-second latency. NVFP4 quantization provides 1.6x throughput over BF16 with 41% energy reduction and only 2-4% quality loss. Self-hosted inference costs $0.001-0.04 per million tokens (electricity only), which is 40-200x cheaper than budget-tier cloud APIs, with hardware breaking even in under four months at moderate volume (30M tokens/day). Our results show that consumer GPUs can reliably replace cloud inference for most SME workloads, except latency-critical long-context RAG, where high-end GPUs remain essential. We provide deployment guidance and release all benchmark data for reproducible SME-scale deployments.